Pair Name | Lycorine, Bortezomib | ||
Phytochemical Name | Lycorine (PubChem CID: 72378 ) | ||
Anticancer drug Name | Bortezomib (PubChem CID: 387447 ) | ||
Structure of Phytochemical |
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MOL
3D
MOL
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Structure of Anticancer Drug |
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2D
MOL
3D
MOL
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Pair Name | Lycorine, Bortezomib | |||
Disease Info | [ICD-11: 2A83] | Multiple myeloma | Investigative | |
Biological Phenomena | Inhibition-->Autophagy | |||
Gene Regulation | Down-regulation | Phosphorylation | BCL2 | hsa596 |
Down-regulation | Expression | BECN1 | hsa8678 | |
Down-regulation | Expression | HMGB1 | hsa3146 | |
Down-regulation | Expression | MAP1LC3B | hsa81631 | |
Down-regulation | Phosphorylation | MAP2K7 | hsa5609 | |
Down-regulation | Phosphorylation | MAPK1 | hsa5594 | |
In Vitro Model | ARH-77 | Plasma cell myeloma | Homo sapiens (Human) | CVCL_1072 |
MM1.S | Plasma cell myeloma | Homo sapiens (Human) | CVCL_8792 | |
NCI-H929 | Plasma cell myeloma | Homo sapiens (Human) | CVCL_1600 | |
In Vivo Model | The mice were subcutaneously inoculated in the flank with 5×10⁶ MM.1S cells in 100 µl of phosphate-buffered saline. | |||
Result | We observed higher HMGB1 expression in bortezomib resistant cells and the combination of bortezomib plus lycorine was highly efficient in vitro and in vivo myeloma models as well as in re-sensitizing resistant cells to bortezomib. These observations indicate lycorine as an effective autophagy inhibitor and reveal that lycorine alone or in combination with bortezomib is a potential therapeutic strategy. |
No. | Title | Href |
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1 | Lycorine Downregulates HMGB1 to Inhibit Autophagy and Enhances Bortezomib Activity in Multiple Myeloma. Theranostics. 2016 Sep 24;6(12):2209-2224. doi: 10.7150/thno.15584. | Click |