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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Lycorine, Bortezomib
Phytochemical Name Lycorine (PubChem CID: 72378 )
Anticancer drug Name Bortezomib (PubChem CID: 387447 )
Structure of
Phytochemical
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2D MOL 3D MOL
Structure of
Anticancer Drug
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 23
Pair Name Lycorine, Bortezomib
Disease Info [ICD-11: 2A83] Multiple myeloma Investigative
Biological Phenomena Inhibition-->Autophagy
Gene Regulation Down-regulation Phosphorylation BCL2 hsa596
Down-regulation Expression BECN1 hsa8678
Down-regulation Expression HMGB1 hsa3146
Down-regulation Expression MAP1LC3B hsa81631
Down-regulation Phosphorylation MAP2K7 hsa5609
Down-regulation Phosphorylation MAPK1 hsa5594
In Vitro Model ARH-77 Plasma cell myeloma Homo sapiens (Human) CVCL_1072
MM1.S Plasma cell myeloma Homo sapiens (Human) CVCL_8792
NCI-H929 Plasma cell myeloma Homo sapiens (Human) CVCL_1600
In Vivo Model The mice were subcutaneously inoculated in the flank with 5×10⁶ MM.1S cells in 100 µl of phosphate-buffered saline.
Result We observed higher HMGB1 expression in bortezomib resistant cells and the combination of bortezomib plus lycorine was highly efficient in vitro and in vivo myeloma models as well as in re-sensitizing resistant cells to bortezomib. These observations indicate lycorine as an effective autophagy inhibitor and reveal that lycorine alone or in combination with bortezomib is a potential therapeutic strategy.
03. Reference
No. Title Href
1 Lycorine Downregulates HMGB1 to Inhibit Autophagy and Enhances Bortezomib Activity in Multiple Myeloma. Theranostics. 2016 Sep 24;6(12):2209-2224. doi: 10.7150/thno.15584. Click
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